List of VEGF/VEGFR inhibitors - Drugs.com
What are VEGF/VEGFR inhibitors? Vascular endothelial growth factor (VEGF)/ vascular endothelial growth factor receptor (VEGFR) inhibitors are agents that inhibit the activity of VEGF and VEGFR. VEGR and VEGFR (a tyrosine kinase receptor) signaling modulates angiogenesis, which involves making of new blood vessels from existing blood vessels.
VEGFR-2 inhibitor - Wikipedia
VEGFR-2 inhibitor, also known as kinase insert domain receptor (KDR) inhibitor, [1] are tyrosine kinase receptor inhibitors that reduce angiogenesis or lymphangiogenesis, leading to anticancer activity. Generally they are small, synthesised molecules that bind competitively to the ATP-site of the tyrosine kinase domain.
Recent advances of anti-angiogenic inhibitors targeting VEGF/VEGFR …
Jan 4, 2024 · Vascular endothelial growth factors (VEGF), Vascular endothelial growth factor receptors (VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic therapy. They constitute a crucial system to …
What are anti-VEGF drugs (VEGF inhibitors)?
Oct 21, 2022 · Anti-VEGF drugs (also called VEGF inhibitors) slow the abnormal growth of blood vessels associated with certain cancers and degenerative eye conditions, such as age-related macular degeneration. Anti-VEGF stands for anti-vascular endothelial growth factor.
Recent progress on vascular endothelial growth factor receptor ...
Jul 7, 2022 · Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis. Currently, VEGFR inhibitors have been widely used in …
Vascular Endothelial Growth Factor Receptor (VEGFR-2)/KDR Inhibitors …
Jun 1, 2019 · From the medicinal chemistry perspective, a wide range of VEGFR-2 inhibitors as potent anti-angiogenic agents are reported for the management of cancer. The current review article is focussing on the structure of VEGFR-2, biology, and medicinal chemistry approaches towards VEGFR-2.
Molecular Mechanisms and Future Implications of VEGF/VEGFR in …
Jan 1, 2023 · Given the importance of the VEGF/VEGFR pathway for multiple aspects of tumor growth and progression, there continues to be novel VEGF/VEGFR-targeting therapies in development. Sulfatinib, also known as surufatinib, is a novel multi-target inhibitor of VEGFR-1/2/3, FGFR1, and CSF1R.
Recent advances of anti-angiogenic inhibitors targeting VEGF/VEGFR …
Jan 3, 2024 · Dozens of inhibitors targeting the VEGF/VEGFR axis have been approved and used in clinic. Many more are undergoing preclinical and clinical trials. In this review, we classify these drugs as inhibitors of the VEGF/VEGFR interaction, inhibitors of VEGFR TK and inhibitors of VEGFR downstream signaling.
A deeper understanding of VEGFR inhibitors - Nature
Oct 12, 2012 · Although vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors are effective at treating renal cell carcinoma, members of this drug class have different clinical...
Recent progress on vascular endothelial growth factor receptor ...
Jul 7, 2022 · This perspective provides an overview of the development of VEGFR dual-target inhibitors from multiple aspects, including rational target combinations, drug discovery strategies, structure–activity relationships and future directions.