Intricacies of TGF-β signaling in Treg and Th17 cell biology
May 23, 2023 · Emerging evidence suggests a broad function for the TGF-β superfamily in Treg and Th17 cell biology. TGF-β superfamily signaling pathways crosstalk and interact with a myriad of other...
Transforming Growth Factor-β Signaling in Regulatory T Cells …
Apr 18, 2017 · TGF-β signals were dispensable for steady-state Treg cell homeostasis and for Treg cell suppression of T cell proliferation and T helper-1 (Th1) cell differentiation. However, Treg cells require TGF-β signals to appropriately dampen Th17 cells and regulate responses in the gastrointestinal tract.
Intricacies of TGF-β signaling in Treg and Th17 cell biology
May 23, 2023 · Here, we introduce the fundamental biology of TGF-β superfamily signaling, Treg cells, and Th17 cells and discuss in detail how the TGF-β superfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks.
The role of transforming growth factor β in T helper 17 ... - PubMed
This review focuses on the perplexing role of TGF-β in Th17 differentiation, depicts the requirement of TGF-β for Th17 development, and underscores the multiple mechanisms underlying TGF-β-promoted Th17 generation, pathogenicity and plasticity.
Regulation of Treg cells by cytokine signaling and co-stimulatory ...
May 13, 2024 · This review explores the signaling pathways of the cytokines that regulate Treg cells, including transforming growth factor beta (TGF-β), interleukin (IL)-2, IL-10, and IL-35, which foster the differentiation and enhance the immunosuppressive capabilities of Tregs.
The Function and Role of the Th17/Treg Cell Balance in …
Dec 15, 2020 · TGF-β acts on the naive CD4 + T cells to induce the development of Th17 cells and Treg cells, while IL-6 induces specific genes in Th17 cells by phosphorylating STAT3, which drives the upregulation of Th17-specific genes, such …
When worlds collide: Th17 and Treg cells in cancer and ... - Nature
Mar 21, 2018 · The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against pathogens...
Transforming Growth Factor-β Signaling in Regulatory T Cells …
Apr 18, 2017 · By generating transgenic mice in which TGF-β receptor I (TGF-βRI) was specifically deleted in Foxp3 + Treg cells (Tgfbr1 f/f Foxp3-cre +), we show that lack of TGF-β signals to Treg cells increased their suppression of Th1 …
Local inhibition of TGF-β1 signaling improves Th17/Treg ... - Nature
Feb 24, 2022 · TGF-β1 is an important growth factor to promote the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). The potential of TGF-β1 as therapeutic target in T cell-mediated...
The Th17 cell-inhibiting cytokine IL-2 is also expressed but is consumed by Treg cells, promoting both Th17 cell development and Treg cell survival. In the absence of TGF-b, IL-6, IL-1b, and IL-23 together drive the development of Th17 cells with a pathogenic phenotype (red circles).