SCG10 is a JNK target in the axonal degeneration pathway
WEBDec 12, 2012 · SCG10 is an axonal protein whose regulation of microtubule dynamics is altered by JNK phosphorylation (22, 24) and therefore is a potentially important downstream effector of JNK-mediated axonal fragmentation following axonal
Self-renewing macrophages in dorsal root ganglia contribute to …
WEBFeb 2, 2023 · Self-renewing macrophages, which proliferate from local resident macrophages, represent the largest population of DRGMacs. The other two subtypes include microglia-like cells and macrophage-like satellite glial cells (SGCs) (Imoonglia). We show that self-renewing DRGMacs contribute to promote axon regeneration.
SCG10, a microtubule destabilizing factor, stimulates the ... - PubMed
WEBSep 1, 2006 · SCG10 is a neuron-specific stathmin protein with a potent microtubule destabilizing factor and is enriched in the growth cones of the developing neurons. We investigated the functional role of SCG10 in neurite outgrowth using rat hippocampal primary cultured neurons.
SCG10‐related neuronal growth‐associated ... - Wiley Online Library
WEBOct 18, 2002 · Recent findings on the roles of stathmin and SCG10-related proteins in microtubule destabilization and its functional block by phosphorylation further support the importance of the SCG10 family proteins in neuronal cytoskeletal regulation, particularly as to microtubule dynamics.
Satellite glial cells promote regenerative growth in sensory …
WEBSep 29, 2020 · SGC also share several properties with astrocytes, including expression of glial fibrillary acidic protein (GFAP) 5,13 and functional coupling by gap junctions 5,14.
SCG10, a neuron-specific growth-associated protein in ... - PubMed
WEBNeuronal growth-associated proteins (nGAPs) are markers of neuronal process outgrowth and are associated with both degenerative and sprouting responses in Alzheimer's disease (AD) brain. To study possible involvement of SCG10, an nGAP, in AD, we cloned human SCG10 cDNA and analyzed SCG-10 at mRNA an ….
Stathmin Family Protein SCG10 Differentially Regulates the …
WEBFeb 21, 2007 · SCG10 (superior cervical ganglia neural-specific 10 protein) is a neuron specific member of the stathmin family of microtubule regulatory proteins that like stathmin can bind to soluble tubulin and depolymerize microtubules.
SCG 10, A neuron-specific growth-associated protein in …
WEBNov 1, 1995 · Neuronal growth-associated proteins (nGAPs) are markers of neuronal process outgrowth and are associated with both degenerative and sprouting responses in Alzheimer's disease (AD) brain. To study possible involvement of SCG10, an nGA,P in AD, we cloned human SCG10 cDNA and analyzed SCG-10 at mRNA and protein levels in control and AD brains.
Phosphorylation of SCG10/stathmin-2 determines multipolar
WEBFeb 6, 2011 · Westerlund and colleagues show that c-Jun N-terminal protein kinase 1 (JNK1), via phosphorylation of SCG10/Stathmin-2, acts as a negative regulator of the rate of neuronal migration and...
SCG10-related neuronal growth-associated proteins in neural
WEBNov 1, 2002 · Recent findings on the roles of stathmin and SCG10-related proteins in microtubule destabilization and its functional block by phosphorylation further support the importance of the SCG10 family proteins in neuronal cytoskeletal regulation, particularly as to microtubule dynamics.
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