Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer …
Mar 27, 2020 · Our study indicated that the STAT1-CCL5 axis is an important modulator in the development of CRC through promoting cell proliferation. Moreover, the levels of STAT1 and CCL5 might be valuable biomarkers for CRC screening.
Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer …
Our study indicated that the STAT1-CCL5 axis is an important modulator in the development of CRC through promoting cell proliferation. Moreover, the levels of STAT1 and CCL5 might be valuable biomarkers for CRC screening.
cGAS–STING drives the IL-6-dependent survival of ... - Nature
Jun 15, 2022 · Here we show that inactivation of cGAS–STING signalling selectively impairs the survival of triple-negative breast cancer cells that display CIN. CIN triggers IL-6–STAT3-mediated signalling...
Macrophage-derived CCL5 facilitates immune escape of
Dec 4, 2019 · C-C motif chemokine ligand 5 (CCL5), which is secreted by macrophages, inhibited T-cell-mediated killing of HT29 cells and promoted immune escape by stabilizing PD-L1 in vitro and in...
A promising research direction for colorectal cancer …
Nov 1, 2022 · The mRNA levels of STAT1 and CCL5 were significantly elevated in CRC tissue specimens, and the upregulation of STAT1-CCL5 axis promoted the proliferation of CRC cells. Tumor buds, CCL5, and fibroblasts further promote angiogenesis and collagen synthesis, ultimately creating a tumor-friendly microenvironment.
Anti-tumor immunity in mismatch repair-deficient colorectal …
Sep 9, 2021 · Treating MC38 cells with inhibitors of STAT1 (fludarabine) or STING (H-151) down-regulated CCL5 and CXCL10 selectively in dMMR but not CIN cells (Fig. 5 E; Haag et al., 2018). We further observed down-regulation in the associated signaling pathways ( Fig. S4 E ).
Upregulation of STAT1-CCL5 axis is a biomarker of colon cancer …
Aug 1, 2020 · STAT1 expression was highly positively correlated with the level of CCL5. The results of the cell counting, EdU, CCK-8, and CFSE staining assays showed that interfering with STAT1 and CCL5...
Proteasome inhibitors restore the STAT1 pathway and enhance …
Nov 10, 2021 · Our study discovered a new biomarker, the STAT1, for immunotherapy on mCRC treatment. We also provided a potential novel rationale for the addition of bortezomib, a proteasome inhibitor, in new immunotherapy combinations for negative STAT1 mCRC.
The mRNA levels of STAT1 and CCL5 in CRC and normal
One study analyzed that the mRNA levels of STAT1 and CCL5 were significantly higher in CRC tissue specimens (the 65 samples of GSE29621) compared to normal colon tissue ( Table 1 NO.1) (57)....
TRIM59 deficiency promotes M1 macrophage activation and …
Jul 12, 2024 · Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway. Introduction. Colorectal cancer (CRC) is a malignancy with an increasing global...
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