Interleukin 23 - Wikipedia
WEBIL-23 is an inflammatory cytokine. It has been shown to be a key cytokine for T helper type 17 cell (Th17 cell) maintenance and expansion. Polarisation to a Th17 phenotype is triggered by IL-6 and TGF-β, which activate the Th17 transcription factor RORγt.
IL-23 past, present, and future: a roadmap to advancing IL-23 …
WEBApr 14, 2024 · The IL-23/Th17 pathway is important for protection against extracellular bacterial and fungal infections, while it appears to be dispensable for protection against most intracellular infections. In contrast, the IL-12/Th1 pathway is required for host responses to intracellular pathogens .
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An Overview
WEBFeb 22, 2021 · IL-23 is mainly produced by macrophages and dendritic cells, in response to exogenous or endogenous signals, and drives the differentiation and activation of T helper 17 (Th17) cells with subsequent production of IL-17A, IL-17F, IL-6, IL-22, and tumor necrosis factor α (TNF-α).
Understanding the IL-23-IL-17 immune pathway - PubMed
WEBIL-23 drives the development of autoreactive IL-17-producing T cells and promotes chronic inflammation dominated by IL-17, IL-6, IL-8 and tumor necrosis factor as well as neutrophils and monocytes.
Interleukin-17 and Interleukin-23: A Narrative Review of …
WEBJan 29, 2021 · The significant efficacy of IL-17A inhibitors in axSpA and the lack of efficacy with the IL-23 inhibitor risankizumab suggest that IL-17A modulates a pathogenic pathway in axSpA, which is independent of IL-23 signaling.
The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From …
WEBNov 16, 2020 · Interleukin-23 (IL-23) plays a pivotal role in stimulating the production of IL-17 by activating the Th17 cells. The IL-23/IL-17 axis is an important pathway for targeted therapy for inflammatory diseases.
The IL-23/IL-17 pathway in human chronic inflammatory …
WEBApr 19, 2019 · Here, we review recent results that document the importance of the IL-23/IL-17 pathway for the pathogenesis of several chronic inflammatory diseases and summarize data that demonstrate...
Role of the IL-23/IL-17 Pathway in Rheumatic Diseases: An …
WEBFeb 21, 2021 · Direct evidence obtained from experimental mouse models confirms the critical role of the IL-23/IL-17 axis in the pathogenesis of arthritis. IL-23p19-deficient (Il23a −/−) mice were protected against the development of collagen-induced arthritis (CIA), a mouse model of RA.
Interleukin-23: as a drug target for autoimmune inflammatory …
WEBTargeting of IL-23 or the IL-23 receptor or IL-23 axis is a potential therapeutic approach for autoimmune diseases including psoriasis, inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis.
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
WEBAug 22, 2014 · Key Points. T helper 17 (T H 17) cells activated by transforming growth factor-β (TGFβ) and interleukin-6 (IL-6) promote mucosal defence, barrier tissue integrity and curtail immunopathogenic ...