Biology of HIF-1α | Cell Death & Differentiation - Nature
Feb 15, 2008 · A well-studied example of how multifaceted the hypoxic response can be is VEGF. VEGF is directly induced by HIF-1α 38 and biological activity is further increased by the hypoxic upregulation...
HIF-1 α pathway: role, regulation and intervention for cancer …
Jun 6, 2015 · Another example involves the HIF-1 transcriptional induction of several pro-angiogenic factors such as the vascular endothelial growth factor (VEGF), which in turn stimulates the development of new blood vessels to enrich tumor …
Critical role of hypoxia sensor--HIF-1α in VEGF gene activation ...
HIF-1α is a transcription factor that under hypoxic conditions, accumulates in endothelial cells and can bind to VEGF gene promoter and induce VEGF gene expression. In order to activate the VEGF gene, HIF-1α must be transported to the nucleus.
Hypoxia and HIF Signaling: One Axis with Divergent Effects
Aug 5, 2020 · The active heterodimeric complex HIF α/β, binding to hypoxia-responsive elements (HREs), determines the induction of at least 100 target genes to restore tissue homeostasis. A growing body of evidence demonstrates that hypoxia signaling can act by generating contrasting responses in cells and tissues.
Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its …
During hypoxia, HIF-1 binds the regulatory region of the VEGF gene, inducing its transcription and initiating its expression [12,15,16]. Such endothelial cells ultimately help to form new blood vessels, supplying the given area with oxygenated blood [ 14 ].
HIF-1, an important regulator in potential new therapeutic …
Nov 1, 2023 · HIF-1 signalling modulates the expression of VEGF, EPO and GLUT-1 associated with neuronal survival, angiogenesis and energy metabolism. HIF-1α shows bidirectional roles in different cells such as neurons and microglia.
Targeting the HIF2–VEGF axis in renal cell carcinoma
Oct 5, 2020 · Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for...
Biology and therapeutic targeting of vascular endothelial growth factor ...
Jul 25, 2023 · Among these, vascular endothelial growth factor A (VEGFA; also known as VEGF) and its two tyrosine kinase receptors, VEGFR1 and VEGFR2, represent a key signalling pathway mediating...
VEGF signaling: Role in angiogenesis and beyond - ScienceDirect
Mar 1, 2024 · Hypoxia in the TME can stimulate the expression of VEGF, primarily through the action of a transcription factor called hypoxia-inducible factor-1 (HIF-1) that binds to hypoxia response elements (HRE) in the promoter regions of various genes, including the VEGF gene.
Role of hypoxia-inducible factor (HIF)-1alpha versus HIF ... - PubMed
Jun 15, 2006 · We found that HIF-1alpha primarily regulates transcriptional activation of VEGF in response to hypoxia and IGF-I compared with HIF-2alpha in MCF-7 cells.