Urinary cast - Wikipedia
[1] As reflected in their cylindrical form, casts are generated in the small distal convoluted tubules and collecting ducts of the kidney, and generally maintain their shape and composition as they pass through the urinary system. Although the most common forms are benign, others indicate disease.
URINARY CASTS: Types, Composition, Significance, Causes, …
Urinary Casts refers to a solid, cylindrical structure that can be found in the microscopic examination of urine sediment. These casts are formed within the kidney’s tubules and may contain various materials, including proteins, cells, or other substances.
Cast formation in the renal tubules - eClinpath
Oct 16, 2013 · With renal tubular injury, epithelial cells slough into the lumen of the renal tubules and are caught up within a mucoprotein matrix made from Tamm-Horsfall protein (hyaline cast). This forms a cellular cast.
Casts - eClinpath
Formation. Cast formation in the renal tubules. A commonly-held theory is that cellular, granular, and waxy casts represent different stages of degeneration of renal tubular epithelial cells in a cast.
Urinary Casts: Different Types and What They Indicate - Healthline
Mar 21, 2023 · A urinary cast is a tube-like structure that forms in urine as the result of conditions, infections, or problems with kidney function.
Hyaline Casts in Urine: What’s Normal vs. High? - Verywell Health
Jan 11, 2024 · Casts are created in the kidney's distal tubules, or collecting ducts, where granular or waxy substances called proteins build up. Often, urine casts can indicate possible kidney disease. Hyaline casts are composed of specific proteins created by the renal cells, which are known as uromodulin.
Hyaline Casts - Osmosis
Jun 17, 2021 · Cast formation takes place in the final portion of the kidney tubules, which consists of the distal convoluted tubules and collecting ducts. It results from the precipitation of Tamm–Horsfall protein (also known as uromodulin) which is secreted by the epithelial tubule cells.
A practical approach to the pathology of renal intratubular casts
May 1, 2020 · This review intends to provide the practical framework to approach the eight most common types of proteinaceous and cellular casts seen in renal biopsies. Herein we summarize the pathologic mechanisms leading to cast formation, along with the …
Casts are protein aggregates formed by the coag-ulation of organic or inorganic substances, such as proteins, crystals, fat, cells, or cell fragments, within the renal tubules and collecting ducts. 3.1.2 Conditions for Cast Formation.
Crystal nephropathies: mechanisms of crystal-induced kidney injury - Nature
Feb 20, 2017 · Light chains, myoglobin or necrotic tubular cells debris enhance cast formation, which can compromise renal function by obstructing the distal tubules 84. The distal tubule is also the site of...