Antiphospholipid syndrome - Wikipedia
Antiphospholipid syndrome, or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies. APS can lead to blood clots (thrombosis) in both arteries and veins, pregnancy-related complications, and other symptoms like low platelets, kidney disease, heart disease, and rash.
Antiphospholipid Syndrome: Symptoms, Diagnosis & Treatment
Aug 19, 2021 · What is antiphospholipid syndrome? Antiphospholipid syndrome (also known as APS, antiphospholipid antibody syndrome or Hughes syndrome) is an autoimmune disorder in which your body’s immune system attacks proteins bound to phospholipids, a certain kind of fat found in all of the cells in your body.
Antiphospholipid Syndrome - StatPearls - NCBI Bookshelf
May 6, 2024 · Antiphospholipid syndrome is characterized by the presence of antiphospholipid antibodies in the setting of thrombosis or pregnancy loss or complications. These antibodies are autoantibodies directed against phospholipid-binding proteins and are composed of …
Antiphospholipid syndrome: Diagnosis - UpToDate
Sep 27, 2024 · Antiphospholipid syndrome (APS) is a clinical and laboratory diagnosis characterized by both persistent laboratory evidence of antiphospholipid antibodies (aPL) and related complications, which may include venous thrombosis, arterial thrombosis, adverse pregnancy outcomes, and nonthrombotic manifestations (eg, heart valve thickening, livedo ...
Diagnosis and Management of the Antiphospholipid Syndrome
May 23, 2018 · The antiphospholipid syndrome is a systemic autoimmune disease defined by thrombotic or obstetrical events that occur in patients with persistent antiphospholipid antibodies. 1 Thrombotic...
Antiphospholipid Syndrome - ACOG
ABSTRACT: Antiphospholipid syndrome (APS) is an autoimmune disorder defined by the presence of characteristic clinical features and specified levels of circulating antiphospholipid antibodies Box 1 and Box 2. Diagnosis requires that at least one clinical and one laboratory criterion are met.
APLA are antibodies directed against certain phospholipids. They are found in a variety of clinical situations. APLA are important to detect because in certain patients they are associated with a syndrome which includes a hypercoagulable state, thrombocytopenia, fetal loss, dementia, strokes, optic changes, Addison's disease, and skin rashes.
Antiphospholipid antibodies and the risk of recurrence after a …
Aug 1, 2013 · Antiphospholipid antibodies (APLA) bind to cardiolipin or to phospholipid-associated plasma proteins such as β 2-glycoprotein I, and prothrombin or annexin A5. 1 APLA occur in a variety of medical conditions (including syphilis and systemic lupus erythematosus) as well as in persons without illness. 2,3 Whether detected as a lupus ...
How to diagnose and manage antiphospholipid syndrome
Dec 8, 2023 · Antiphospholipid antibodies (aPL) are autoimmune antibodies directed toward phospholipids or phospholipid-protein complexes, particularly those containing β2-glycoprotein I (β2GPI). Persistently positive aPL accompanied by arterial or venous thrombosis, or recurrent pregnancy loss, constitutes the antiphospholipid syndrome (APS).
Positive antiphospholipid antibodies: observation or treatment?
Antiphospholipid antibodies (APLAs) are primarily directed toward phospholipid-binding proteins and are responsible for thrombotic events. APLAs include anti-β2Glycoprotein I (anti-β2GPI), anticardiolipin (anti-CL) antibodies, and lupus anticoagulant.
- Some results have been removed