T-cell receptor - Wikipedia
WEBThe T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, [1] that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
TCR-T cell therapy: current development approaches, preclinical ...
WEBTCR-T cells are more sensitive to antigen levels in tumor cells compared to CAR-T cells and have the ability to recognize not only surface antigens but also intracellular antigens, making them applicable to a broader spectrum of tumors . Moreover, TCR-T cells may demonstrate greater efficacy in the complex microenvironment of solid tumors, as ...
TCR-engineered T cell therapy in solid tumors: State of the art and ...
WEBFeb 15, 2023 · TCR-T and CAR-T cell therapies consist in genetically engineered T cells, modified to express a receptor directed against a tumor antigen. CAR-T cell therapies were a considerable breakthrough in hematological cancers, with six therapies now FDA-approved, targeting CD19 or B cell maturation antigen (5, 6).
T cell receptor (TCR) signaling in health and disease
WEBDec 13, 2021 · This review provides a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and will discuss their role in...
Cancer Therapy With TCR-Engineered T Cells: Current Strategies ...
WEBMar 3, 2022 · To redirect T cells against tumor cells, T cells can be engineered ex vivo to express cancer-antigen specific T cell receptors (TCRs), generating products known as TCR-engineered T cells (TCR T). Unlike chimeric antigen receptors (CARs), TCRs recognize HLA-presented peptides derived from proteins of all cellular compartments.
Recent insights of T cell receptor-mediated signaling pathways for T ...
WEBMay 21, 2020 · T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell receptor (TCR) complexes.
T cell receptor therapeutics: immunological targeting of the
WEBOct 27, 2023 · The T cell receptor (TCR) complex is a naturally occurring antigen sensor that detects, amplifies and coordinates cellular immune responses to epitopes derived from cell surface and...
The recent advancement of TCR-T cell therapies for cancer
WEBMay 25, 2024 · TCR-T cell therapy, which involves introducing exogenous TCRs into patients' T cells, is a novel cell therapy strategy. TCR-T cell therapy can target the entire proteome of cancer cells. Engineering T cells with exogenous TCRs to help patients combat cancer has achieved success in clinical trials, particularly in treating solid tumors.
TCR-T Immunotherapy: The Challenges and Solutions - Frontiers
WEBJan 24, 2022 · T cell receptor-engineered T cell (TCR-T) therapy is free from the limit of surface antigen expression of the target cells, which is a potential cellular immunotherapy for cancer treatment.
How Tecelra® is Transforming TCR-T Cell Therapy - News-Medical.net
WEB2 days ago · This approval signifies the first T-cell receptor (TCR) therapy for solid tumors specifically targeting unresectable or metastatic synovial sarcoma in adults. Tecelra’s success offers patients ...