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  1. Simeprevir - Wikipedia

    • Simeprevir is indicated treating chronic hepatic C (CHC) infection as a part of a triple antiviral treatment regimen consisting of two other drugs: peginterferon-alfa (PEG-IFN) and ribavirin (RBV). It is primarily effe… See more

    Contraindications

    Any contraindications that apply to peg-IFN and RBV apply to simeprevir since they must be used in combination during treatment of CHC. For example, people with sickle … See more

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    Adverse Effects

    Severe itching (22%), sensitivity to sunlight (5%), and rash (25%) are some of the common … See more

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    Mechanism of Action

    Simeprevir is a hepatitis C virus protease inhibitor. Simeprevir is a NS3/4A protease inhibitor, thus preventing viral maturation through inhibition of protein synthesis. Simeprevir … See more

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    Pharmacokinetics

    Simeprevir is orally bioavailable. Its absorption increases when taken with food, and is therefore advised to be taken with food. The liver's CYP3A4 enzymes mainly break dow… See more

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    Pharmacogenomics

    According to simeprevir's prescriber information, its efficacy in combination with peginterferon alfa and ribavirin is "substantially reduced in people with HCV genotype 1… See more

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  1. HCV NS3/4A protease
    • According to 3 sources
    Simeprevir is a direct-acting antiviral agent and inhibitor for HCV NS3/4A protease, which is an important enzyme required for viral replication. Unlike Boceprevir and Telaprevir, simeprevir is a competitive, reversible, macrocyclic, noncovalent inhibitor.
    Simeprevir is an inhibitor of HCV NS3/4A protease, a protease that is essential for viral replication. It is considered a direct-acting antiviral treatment for HCV, also called a specifically targeted antiviral therapy for HCV (STAT-C).
    Simeprevir is an inhibitor of HCV NS3/4A protease, a protease that is essential for viral replication. It is considered a direct-acting antiviral treatment for HCV, also called a specifically targeted antiviral therapy for HCV (STAT-C).
  2. Simeprevir: Uses, Interactions, Mechanism of Action - DrugBank …

  3. Simeprevir: Indications, Side Effects, Warnings - Drugs.com

  4. Discovery and Development of Simeprevir (TMC435), a …

    Jan 21, 2014 · Here we summarize the extensive medicinal chemistry effort to develop novel P2 cyclopentane macrocyclic inhibitors guided by HCV NS3 protease assays, the cellular replicon system, structure-based design, and a …

  5. Simeprevir: a macrocyclic HCV protease inhibitor - PubMed

  6. Simeprevir (Professional Patient Advice) - Drugs.com

  7. Simeprevir for the treatment of hepatitis C virus infection

  8. Simeprevir: first global approval - PubMed

  9. Simeprevir: a review of its use in patients with chronic ... - PubMed

  10. Simeprevir: Dosage, Mechanism/Onset of Action, Half-Life