Simeprevir Protease Inhibitor

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Simeprevir - Wikipedia
Simeprevir is indicated treating chronic hepatic C (CHC) infection as a part of a triple antiviral treatment regimen consisting of two other drugs: peginterferon-alfa (PEG-IFN) and ribavirin (RBV). It is primarily effe… See more
Contraindications
Any contraindications that apply to peg-IFN and RBV apply to simeprevir since they must be used in combination during treatment of CHC. For example, people with sickle … See more
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Adverse Effects
Severe itching (22%), sensitivity to sunlight (5%), and rash (25%) are some of the common … See more
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Mechanism of Action
Simeprevir is a hepatitis C virus protease inhibitor. Simeprevir is a NS3/4A protease inhibitor, thus preventing viral maturation through inhibition of protein synthesis. Simeprevir … See more
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Pharmacokinetics
Simeprevir is orally bioavailable. Its absorption increases when taken with food, and is therefore advised to be taken with food. The liver's CYP3A4 enzymes mainly break dow… See more
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How HCV protease inhibitors work
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Pharmacogenomics
According to simeprevir's prescriber information, its efficacy in combination with peginterferon alfa and ribavirin is "substantially reduced in people with HCV genotype 1… See more
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Table of Contents
Contraindications
Adverse Effects
Mechanism of Action
Pharmacokinetics
Pharmacogenomics

HCV NS3/4A protease
According to 3 sources
Simeprevir is a direct-acting antiviral agent and inhibitor for HCV NS3/4A protease, which is an important enzyme required for viral replication. Unlike Boceprevir and Telaprevir, simeprevir is a competitive, reversible, macrocyclic, noncovalent inhibitor.
Simeprevir: Uses, Interactio…
go.drugbank.com
Simeprevir is an inhibitor of HCV NS3/4A protease, a protease that is essential for viral replication. It is considered a direct-acting antiviral treatment for HCV, also called a specifically targeted antiviral therapy for HCV (STAT-C).
Simeprevir: Dosage, Mecha…
medicine.com
Simeprevir is an inhibitor of HCV NS3/4A protease, a protease that is essential for viral replication. It is considered a direct-acting antiviral treatment for HCV, also called a specifically targeted antiviral therapy for HCV (STAT-C).
Simeprevir: Dosage, Mecha…
medicine.com
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People also ask
Is simeprevir a protease inhibitor?
Abstract Simeprevir (TMC435, Olysio™), a second-generation hepatitis C virus (HCV) protease inhibitor, has been recently approved for the treatment of genotype 1 chronic hepatitis C in combination with pegylated interferon and ribavirin. This molecule has very different characteristics from first-generation protease inhibitors.
Simeprevir for the treatment of hepatitis C virus infection
ncbi.nlm.nih.gov
How effective is simeprevir compared with peginterferon alfa and ribavirin?
According to simeprevir's prescriber information, its efficacy in combination with peginterferon alfa and ribavirin is "substantially reduced in people with HCV genotype 1a with an NS3 Q80K polymorphism at baseline compared to people infected with HCV genotype 1a without Q80K polymorphism."
Simeprevir - Wikipedia
en.wikipedia.org
What happens if Simeprevir is combined with infigratinib?
Simeprevir may decrease the excretion rate of Indomethacin which could result in a higher serum level. The metabolism of Infigratinib can be decreased when combined with Simeprevir. The risk or severity of hypoglycemia can be increased when Simeprevir is combined with Insulin aspart.
Simeprevir: Uses, Interactions, Mechanism of Action | DrugBank Online
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Simeprevir: Uses, Interactions, Mechanism of Action - DrugBank …

938 rows · Simeprevir is a direct-acting antiviral agent and inhibitor for HCV NS3/4A …

DRUG	INTERACTION
1,2-Benzodiazepine	The metabolism of 1,2-Benzodiazepine can ...
Abametapir	The serum concentration of Simeprevir can ...
Abemaciclib	The serum concentration of Abemaciclib ...
Abiraterone	The metabolism of Simeprevir can be ...

See all 938 rows on go.drugbank.com

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HCV Protease Inhibitor

Simeprevir Mechanism of Action