Chromatin - Wikipedia
With addition of H1, during mitosis the beads-on-a-string structure can coil into a 30 nm-diameter helical structure known as the 30 nm fibre or filament. The precise structure of the chromatin fiber in the cell is not known in detail.
30 nm Fibers - (Anatomy and Physiology I) - Fiveable
Explain the role of 30 nm fibers in the organization and structure of chromatin. The 30 nm fibers represent the secondary level of chromatin organization, where the primary 10 nm fibers (nucleosomes) are further folded and compacted to create a more condensed structure.
30 nm fiber - (Molecular Biology) - Fiveable
The 30 nm fiber is a structural form of chromatin that represents the next level of DNA packaging in eukaryotic cells, consisting of nucleosomes coiling together into a more compact structure.
A variable topology for the 30-nm chromatin fibre - PMC
Aug 14, 2007 · The structure of the 30-nm chromatin fibre is an important determinant of the regulation of eukaryotic transcription. A fundamental issue is whether the stacking of nucleosomes in this fibre is organized as a one-start or two-start helix.
Structure and organization of chromatin fiber in the nucleus
Apr 22, 2015 · Our 3D cryo-EM structure of 30-nm chromatin fiber provides an excellent starting point for the elucidation of the fundamental structural aspects of the elusive 30-nm chromatin fiber.
30 nm fiber - Vocab, Definition, and Must Know Facts - Fiveable
The 30 nm fiber is a structural form of chromatin that plays a critical role in the packaging of DNA within the nucleus. This fiber consists of nucleosomes, which are formed by DNA wrapped around histone proteins, further coiling and folding to achieve a more compact organization of genetic material, allowing for efficient storage and ...
Higher-Order Structures of Chromatin: The Elusive 30 nm Fiber
Feb 23, 2007 · Although there is a lack of in vivo evidence that the 30 nm fiber exists in higher eukaryotes, the ability to assemble this structure in vitro and extract it from nuclei argue that the 30 nm fiber is a distinct secondary higher-order chromatin structure.
Higher-order structure of the 30-nm chromatin fiber revealed
We have recently reconstituted the 30 nm chromatin fibers from 12 nucleosomal arrays in vitro in the presence of linker histone H1, and determined their cryo-EM structures at resolution of 11 Å (Song et al., Science 344, 376-380).
The 30-nm Fiber Redux | Science - AAAS
Apr 25, 2014 · Does it correspond to the “native” 30-nm fiber with fewer nucleosomes per turn or to an alternative structure? And does unwinding of the fiber involve change to internucleosomal interactions? The alternating stacking suggests the potential for finetuning epigenetic marks and array organization.
EM measurements define the dimensions of the “30-nm” chromatin fiber …
Apr 4, 2006 · Our measurements of fiber dimensions and tight nucleosome packing provide strong constraints for modeling the 30-nm chromatin fiber. Initially, we attempted to construct a model using both one- and two-start helical arrangements.