New Medications for the Treatment of Cocaine Dependence
For the prevention of relapse, medications that block cocaine euphoria or reduce cocaine craving have shown promise. Potential relapse-prevention medications include GABAergic medications, such as baclofen, tiagabine, and topiramate, and the glutamatergic medication, modafinil.
Cocaine and Beta Blockers: All It’s Cracked Up to Be?
Aug 29, 2017 — Carvedilol and labetalol, two beta blockers with concomitant alpha-blocking activity, have been proposed as a reasonable alternative in patients who continue to use cocaine, as they would provide similar clinical benefits while moderating the theoretical alpha-mediated effects of cocaine.
Cocaine Toxicity - StatPearls - NCBI Bookshelf
Jun 8, 2023 — Cocaine can be snorted, swallowed, injected, or smoked. Its pharmacodynamics involves multiple complex mechanisms, although its half-life is short at about 1 hour. This drug binds and blocks monoamine (dopamine, norepinephrine, and serotonin) reuptake transporters with equal affinity.
Cocaine - Wikipedia
Cocaine blocks the dopamine transporter, [ 21 ] inhibiting reuptake of dopamine from the synaptic cleft into the pre-synaptic axon terminal; the higher dopamine levels in the synaptic cleft increase dopamine receptor activation in the post-synaptic neuron, [ 22 ][ 23 ] causing euphoria and arousal. [ 24 ]
What are the effects of cocaine on the brain? - Medical News Today
Aug 4, 2023 — Cocaine is a highly addictive stimulant drug that can have both short- and long-term effects on the brain, including irritability, paranoia, and impaired cognitive functions.
The Neurobiology of Cocaine Addiction - PMC - National Center …
Snorted, smoked, or injected, cocaine rapidly enters the bloodstream and penetrates the brain. The drug achieves its main immediate psychological effect—the high—by causing a buildup of the neurochemical dopamine. Dopamine acts as a pacesetter for …
Does Using Cocaine Kill Brain Cells? - Healthline
Feb 17, 2020 — Using cocaine does kill brain cells over time. Cocaine can alter individual brain cells and entire regions of the brain. Stopping may help your brain recover, but some effects may be...
Cocaine: Mechanism and Effects in the Human Brain
Jan 1, 2014 — Cocaine actually blocks the uptake of the monoamine neurotransmitters, not just dopamine, and also increases the concentrations of serotonin and norepinephrine (Carroll et al., 1992; Lewin et al., 1992).
Cocaine Addiction: Definition, Symptoms, Causes, Treatment
Jun 22, 2022 — Cocaine addiction is a complex disease the often involves crack cocaine and multiple drug addictions. Learn the signs of abuse and where to find treatment.
Cocaine Toxicity: Practice Essentials, Background, Pathophysiology
In the heart, cocaine acts as a Vaughan Willaims IC sodium channel blocker. Cocaine also blocks potassium channels. In some cellular membranes, it may block sodium-calcium exchange.