Despite being a remarkable medical advancement, organ transplants still face the critical issue of rejection by the immune ...

Breakthrough research by UVA biomedical engineering professor Evan Scott and team uses nanoparticles to help the body accept ...

Organ transplantation is an incredible medical accomplishment that unfortunately still presents significant unsolved challenges, including rejection ...

Studies have shown that the factors that promote the healing of diabetic foot ulcer are related to inhibiting apoptosis, promoting fibrocyte proliferation, promoting angiogenesis, accelerating ...

A new functional state of macrophages and microglia has been identified in human ... in cancer can be traced to a “trinity” of transcription factors: c-MYC, HIF-1, and p53 (Yeung et al., 2008). The ...

Reduced blood oxygen levels lead to decreased expression of hypoxia-inducible factor-1α (HIF-1α ... Hypoxic environments negatively affect various cells, including ECs, macrophages, keratinocytes, and ...

Intercorrelation networks were observed between enzymes of the PPP (eg, transketolase) and macrophage ... TKT and HIF-1α (Abcam, Cambridge, Massachusetts, USA; BioLegend, San Diego, California, USA) ...

Intrinsic glycolytic metabolism shapes PD-L1 + macrophages with antitumourigenic properties in HCC. PKM2/HIF-1α axis, elicited by hepatoma cell-derived fibronectin 1, triggers pluripotent polarisation ...