T he main neuropathological feature of Parkinson's disease is the loss of dopaminergic neurons in the substantia nigra pars compacta. Specifically, dopaminergic neurons in the ventral tier of the ...

Researchers have discovered how a cell surface protein called Aplp1 can play a role in spreading material responsible for ...

More information: Bart de Laat et al, Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease, npj Parkinson's Disease (2024).

Idiopathic Parkinson’s disease (IPD) is a central nervous system disorder affecting the basal ganglia that is caused by death of dopamine-producing cells in the substantia nigra. Although IPD is ...

The substantia ... [+] nigra plays an important role in reward, addiction, and movement. Degeneration of this structure is characteristic of Parkinson's disease. In late 2018, Japanese ...

Parkinson's disease (PD ... Neurodegeneration in PD critically involves the dopaminergic neurons of the substantia nigra pars compacta, which results in a severe reduction in dopamine levels ...

When they analysed the substantia nigra they recorded a rapid loss of Substance P (a ... Our work identifying that a silent stroke can lead to Parkinson’s disease shows it is more important than ever ...

Favre is 54 years old. These symptoms have to do with the substantia nigra, the part of the brain that controls motor skills. When someone has Parkinson's, there will be degeneration in this part ...

Ashery said that Parkinson’s is characterized by the destruction of neurons that produce dopamine in the midbrain’s substantia nigra area. By the time the motor symptoms of Parkinson’s ...

Parkinson’s disease (PD ... the degeneration of dopamine-producing neurons in a brain area called the substantia nigra. Recently, research has shown that PD also affects the cerebellum ...

Parkinson's is a progressive nervous system ... particularly in an area called the substantia nigra, which produces dopamine, a chemical that -- in addition to heavily impacting mood -- acts ...