Background: Aluminium-containing phosphate binders have long been used for treatment of hyperphosphatemia in dialysis patients. Their safety became controversial in the early 1980's after reports ...

A recent study has demonstrated that phosphate binders are safe and effective for controlling phosphorus levels in patients on peritoneal dialysis (PD). “Phosphate control strategies should be ...

Employees of the Institute of Chemistry of Kazan Federal University and the Kazan National Research Technical University have ...

on dialysis as add-on therapy in patients who have inadequate response to phosphate binders or who are intolerant of any dose ...

In short, the latter indication is for phosphate binder refractory DD-CKD patients with hyperphosphatemia. IBSRELA was approved in March 2022 and XPHOZAH in October 2023. Tenapanor is a sodium ...

Take with meals. Starting dose for adult patients not taking a phosphate binder: Serum phosphorus >5.5 and <7.5mg/dL: 800mg 3 times daily. Serum phosphorus ≥7.5mg/dL: 1.6g 3 times daily.

Sevelamer hydrochloride has the potential to reduce serum phosphorus levels without promoting arterial calcification (which can result from use of calcium-based oral phosphate binders [OPBs]) and ...

Despite a prolific number of studies of the dysregulation of these minerals in CKD and the potential interventions to bring them back into a normal range, outcomes are uncertain and some of these ...

At the U.S. Food and Drug Administration's (FDA's) Cardiovascular and Renal Drugs Advisory Committee meeting today, the majority of members voted to recommend the use of phosphate binders ...

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Caution with concomitant digitalis compounds; increased toxicity. Concomitant aluminum-containing preparations (eg, antacids, phosphate binders); may cause aluminum bone toxicity.

In summary, the historical data which have raised concern about neurological and bone toxicity of aluminium-based phosphate binders may no longer be relevant to contemporary practice. This is due ...