The helicase components shown are the minichromosome maintenance (MCM) helicase 2-7 hexamer, CDC45, and associated GINS complex (simplified as a single entity here). The ssDNA is coated in RPA ...
The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer.
in controlling fork progression and origin activation by inhibiting the activities of the replicative DNA helicase, CMG (Cdc45-MCM-GINS), and the cell cycle-regulated protein kinase, DDK ...