The immune system has many pathways to protect the body from infection, but sometimes an overactive immune response results in autoimmune diseases including IBD, psoriasis, rheumatoid arthritis and ...

The IL-23/IL-23R signalling pathway plays a vital role in the pathogenesis of plaque psoriasis and other immune-mediated inflammatory diseases. JNJ-2113 selectively inhibits IL-23 signalling and ...

I think we haven't yet come to a consensus as to whether there's a specific and key pathway, akin to the IL-17/IL-23 pathway that we see in plaque psoriasis, that we can block safely and improve ...

In parallel, neutralizing antibodies targeting other pathways of the immune system have been developed and tested. Antibodies targeting IL-12/IL-23 pathways, and proinflammatory cytokines such as ...

IL-23 initiates and perpetuates both innate and ... Overall, these findings suggest that agents affecting LTB4 biosynthetic pathways may prove useful for primary or secondary prevention of heart ...

The company also intends to move an XmAb bispecific antibody targeting TL1A and IL-23 pathways for IBD in 2026. While Xencor’s decision to advance four new candidates in the autoimmune disease ...

The majority of gastroenterologists preferred Skyrizi over Stelara in terms of overall efficacy, aligning with the results of the SEQUENCE trial, which demonstrated Skyrizi's superior efficacy in a ...

Plaque psoriasis, the most common form of psoriasis (about 90 per cent of cases), is a chronic inflammatory autoimmune ...

The mTOR pathway is activated in phagocytes in response ... in the production of pro-inflammatory cytokines, such as IL-12, IL-23 and IL-6, and a decrease in the production of the anti ...

Explore our betting preview for the Utah Utes and Arizona State Sun Devils football game, in their first matchup as Big 12 ...

The company also intends to move an XmAb bispecific antibody targeting TL1A and IL-23 pathways for IBD in 2026. While Xencor’s decision to advance four new candidates in the autoimmune disease space ...