The allele frequency represents the incidence of a gene variant in a population. Alleles are variant forms of a gene that are located at the same position, or genetic locus, on a chromosome.

with a particular focus on the major neurotransmitter systems and neuroplasticity. ↔ 5-HTT binding (PC, OC, HYP, MB) in early adolescent ↔ 5-HTT binding in late adolescent ...

"VO659's allele-preferential action and direct targeting ... expansion in the coding region of exon 1 of the huntingtin (HTT) gene, which results in production of mutant HTT protein (mHTT) with ...

1 Homozygous for allele r rr Wrinkled 2 Homozygous for allele R RR Round Plants 2 and 3 both have the same phenotype even though they have different genotypes. This is because the effect of allele ...

Differential effects on the serotonin system (such as regional 5-HTT upregulation and the absence of typical desensitization in serotonergic receptor function) likely underlie differential ...

First clinical data of VO659 demonstrated 28% mean reduction in CSF mutant HTT at day 85 in HD patients ... an investigational allele-preferential antisense oligonucleotide (ASO) therapy.