In particular, macrophage immune cells depend on proteins that are activated by hypoxia. They can promote inflammation or suppress it, depending on what "awakened" them. For example, HIF-1 proteins ...

Our version 1.0 research model zoomed in ... also associated with HIF-1α, between HCC cells and tumour-associated macrophages in a hypoxic microenvironment. Tell us how you approach HCC recurrence.

Despite being a remarkable medical advancement, organ transplants still face the critical issue of rejection by the immune ...

Breakthrough research by UVA biomedical engineering professor Evan Scott and team uses nanoparticles to help the body accept ...

They found that the protein HIF-2a was present in the macrophages—a type of white blood cell—of mice that tolerated the transplant, but not in those that experienced rejection. HIF-2a ...

Inflammatory processes are the body’s defence against local damage and disease. Inflammation involves the influx into organs of immune cells (white blood cells) from the blood. These cells deal with ...

The following is a summary of “Metabolic reprogramming of macrophages in cancer therapy,” published in the September 2024 ...

When they detect a threat, myeloid cells called monocytes can transform into inflammatory macrophages -- attack cells that deal with intruders. Targeting HIF-2α: A New Therapeutic Strategy Dr. Scott's ...

Study identifies pro-inflammatory macrophage subtype with distinct genetic features in inflamed joints of RA patients.

Thus, the elucidation of TAM–tumor cell interactions in animal models fits with the clinical observation of poor outcomes in breast cancers with central necrosis. [53] Those tumors with necrosis ...

Acute kidney injury (AKI) is associated with a poor prognosis, and no effective treatment has been established to date. Understanding the mechanisms that prevent the progression of AKI is crucial.