Specific mutations in LMNA, many of which affect farnesylation of the C terminus of lamin A, function dominantly to give rise to HGPS. Farnesylation inhibitors effectively suppress disease ...
First his team published a major paper in Cell showing that to signal effectively, Ras proteins must undergo a process called farnesylation to become associated with the cell membrane. The finding ...
Smallwood, D.T., Apollonio, B., Willimott, S., Ambrose, A., Alharthi, A., Ramsay, A.G., Wagner, S.D. (2016) Extracellular vesicles released by CD40/IL-4 stimulated ...