M24B aminopeptidase inhibitors selectively activate the CARD8
WEBFeb 14, 2022 · In this Article we identify and characterize M24B aminopeptidase inhibitors, which induce the accumulation of proline-containing peptides that weakly inhibit DPP8/9 as selective activators of the...
Optimized M24B Aminopeptidase Inhibitors for CARD8 …
WEBFeb 1, 2023 · We recently reported that a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 called CQ31 selectively activates the CARD8 inflammasome by inducing the build-up of Xaa-Pro peptides.
M24B aminopeptidase inhibitors selectively activate the CARD8 ...
WEBIn this Article we identify and characterize M24B aminopeptidase inhibitors, which induce the accumulation of proline-containing peptides that weakly inhibit DPP8/9 as selective activators of the CARD8 inflammasome.
M24B aminopeptidase inhibitors selectively activate the CARD8 ...
WEBHere we report a small molecule called CQ31 that selectively activates CARD8. CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.
WEBHere we report a small molecule called CQ31 that selectively activates CARD8. CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the ...
XaaP-ing DPP8/9 for CARD8 activation - Nature Chemical Biology
WEBFeb 14, 2022 · A new paper reveals that inhibition of M24B aminopeptidases drives the selective activation of the CARD8 inflammasome, providing new insights into its regulation.
Optimized M24B Aminopeptidase Inhibitors for CARD8 ... - PubMed
WEBFeb 23, 2023 · We recently reported that a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 called CQ31 selectively activates the CARD8 inflammasome by inducing the build-up of Xaa-Pro peptides.
M24B aminopeptidase inhibitors selectively activate the CARD8 ...
WEBMay 1, 2022 · We recently reported that a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 called CQ31 selectively activates the CARD8 inflammasome by inducing the build-up of Xaa...
Optimized M24B aminopeptidase inhibitors for CARD8 …
WEBOptimized M24B aminopeptidase inhibitors for CARD8 inflammasome activation: Abstract: Inflammasomes are innate immune signaling platforms that trigger pyroptotic cell death. NLRP1 and CARD8 are related human inflammasomes that detect similar danger signals, but NLRP1 has a higher activation threshold and triggers a more inflammatory form of ...
The NLRP1 and CARD8 inflammasomes detect reductive stress
WEBJan 31, 2023 · We recently reported that the oxidized form of TRX1 binds to NLRP1 and represses inflammasome activation. These findings suggested that intracellular reductive stress, which would reduce oxidized TRX1 and thereby abrogate the NLRP1-TRX1 interaction, is an NLRP1 inflammasome-activating danger signal.