Chemical scissor–mediated structural editing of layered ... - Science
WEBMar 16, 2023 · The chemical scissor–mediated structural editing protocol contains four reaction routes : (i) the opening of non-vdW gaps in MAX phases by LAMS scissors because of differences in redox potential between Lewis acidic cations and A elements (route I), (ii) the diffusion of metal atoms into interlayer atom vacancies to form MAX …
Chemical remodeling of a cellular chaperone to target the
WEBTheir complex formation was the product of purposeful, structure-guided chemical modifications to mold a high-affinity binding interface between CYPA and active KRAS G12C. The target-directed approach described here differs from other pharmacologic or proteomic screens that describe the identification of rapamycin or sangliferin analogs …
Designing for a green chemistry future | Science - AAAS
WEBJan 24, 2020 · Today’s chemical sector follows a linear path (Fig. 1, left), in which feedstocks, mostly fossil and finite in nature, are pushed through a production chain that relies on reagents that are designed to be highly reactive but are often also unintentionally persistent and/or toxic, which is consequential for worker exposure as well as accidental …
Chemical Glycobiology | Science - AAAS
WEBChemical synthesis and enzyme-based routes are complementary. Enzymes can be used to effect glycosylation with absolute regio- and stereo-control. If the necessary enzyme is available, the desired bond can be formed (Fig. 2A), often with high efficiency. In comparison, chemical synthesis offers exceptional flexibility.
Chemical vapor deposition of layered two-dimensional MoSi
WEBAug 7, 2020 · Funding: Supported by the National Natural Science Foundation of China (nos. 51325205, 51725103, 51290273, 51521091, and 51671193), the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (no. ZDBS-LY-JSC027), the Strategic Priority Research Program of the Chinese Academy of Sciences (no. …
An indoor chemical cocktail | Science - AAAS
WEBFeb 9, 2018 · The building science research community has long identified the importance of ventilation for the state of indoor environments. Open windows expose us to outdoor air, whereas well-sealed houses are subject to emissions from furnishings, building materials, chemical reactions, and people and their activities.
Industrial biomanufacturing: The future of chemical production
WEBJan 6, 2017 · The development and use of chemical processes was a major part of this shift, as chemical techniques for the large-scale production of compounds such as sulfuric acid, bleaching powder, and soda ash in the 18th century helped transform and shape the production of glass, textiles, soaps, and paper (3–5). These chemical processes laid the ...
The importance of synthetic chemistry in the pharmaceutical
WEBJan 18, 2019 · Chemical synthesis plays a key role in pharmaceutical research and development. Campos et al. review some of the advantages that have come from recent innovations in synthetic methods. In particular, they highlight small-molecule catalysts stimulated by visible light, enzymes engineered for versatility beyond their intrinsic …
Flyby reaction trajectories: Chemical dynamics under ... - Science
WEBJul 9, 2021 · To investigate the postulated role of force in inducing and controlling NDEs, we chose a cyclobutane ring-opening reaction that follows a stepwise mechanism (23–25), is mechanochemically active (25–27), and exhibits a distribution …
Chiral-structured heterointerfaces enable durable perovskite
WEBMay 23, 2024 · Mechanical failure and chemical degradation of device heterointerfaces can strongly influence the long-term stability of perovskite solar cells (PSCs) under thermal cycling and damp heat conditions. We report chirality-mediated interfaces based on R-/S-...