GARD - Genetic and Rare Diseases Information Center
WEBAttenuated familial adenomatous polyposis (AFAP) is an inherited condition that increases the chance to develop cancer of the large intestine (colon) and rectum. It is a milder form of classic familial adenomatous polyposis (FAP).
WEB• Typically, families with AFAP syndrome have one or more of the following features: o Many colon polyps (also called polyposis), typically ranging from 10 to less than 100. o Colon cancer diagnosed in the 50’s-60’s.
Familial adenomatous polyposis: Screening and management of ... - UpToDate
WEBMay 10, 2024 · An attenuated form of FAP (AFAP) is characterized by few colorectal adenomas with a later age of onset and an 80 percent lifetime risk of CRC. Patients with FAP are also at risk for several extracolonic malignancies. This chapter will review the management of FAP.
Attenuated Familial Adenomatous Polyposis - ScienceDirect
WEB‘Attenuated’ familial adenomatous polyposis (AFAP) AFAP is a subgroup of FAP in which patients have milder manifestations compared to classic FAP. AFAP patients have less than 100 polyps, later onset of colorectal adenomas and probably a …
Familial adenomatous polyposis - Symptoms and causes
WEBJun 30, 2021 · Familial adenomatous polyposis (FAP) is a rare, inherited condition caused by a defect in the adenomatous polyposis coli (APC) gene. Most people inherit the gene from a parent. But for 25 to 30 percent of people, the …
Familial Adenomatous Polyposis (FAP) - Fight Colorectal Cancer
WEBMar 31, 2024 · Familial adenomatous polyposis (FAP) is a hereditary syndrome in which hundreds to thousands of polyps grow inside the colon and rectum. These polyps usually start to form during the teenage years and – if left untreated – almost always turn into colorectal cancer.
Attenuated Fap | Cancer in the Family - cancronafamilia.org
WEBAbout 8% of the families with FAP have an attenuated version of disease (called AFAP). AFAP is caused by hereditary mutations in the same APC gene as FAP, but the two affect different parts of the gene.
2020 ASGE Recommendations for Endoscopy in Familial …
WEBMar 31, 2020 · Because AFAP is characterized by a later onset of polyps and a lower risk of colorectal cancer, the ASGE recommends a screening colonoscopy for patients with or suspected of having AFAP starting at the age of 18 to 20 years.
Familial Adenomatous Polyposis - The Jackson Laboratory
WEBFamilial adenomatous polyposis (FAP) is a cancer predisposition syndrome and includes a milder, attenuated form (AFAP) of the disease. Individuals with FAP develop hundreds to thousands of adenomatous polyps in their colon, sometimes beginning in childhood.
Appropriate Management of Attenuated Familial Adenomatous …
WEBMar 5, 2019 · Hereditary polyposis syndromes in which APC gene germline mutations can lead to colorectal carcinogenesis are familial adenomatous polyposis (FAP), attenuated FAP (AFAP) and MUTYH-associated polyposis. All 3 syndromes increase the potential for the development of colorectal cancer.